![]() Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is the most recently defined inflammatory demyelinating disease of the central nervous system (CNS). 8Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.7Department of Neurology, Mayo Clinic, Jacksonville, FL, United States.6Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.5Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.4Department of Ophthalmology, Mayo Clinic, Rochester, MN, United States.3Department of Neurology and Center for Multiple Sclerosis and Autoimmune Neurology Mayo Clinic, Rochester, MN, United States.2Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.1Neurology Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.Chen 3,4 Sara Mariotto 5 Giulia Fadda 6 Alessandro Dinoto 5 A. Accessed April 26, 2022.Elia Sechi 1 Laura Cacciaguerra 2,3 John J. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Clinical features and diagnosis. Pathogenesis and epidemiology of multiple sclerosis. In: Harrison's Principles of Internal Medicine. Signs and symptoms consistent with demyelinating disease.Atypical inflammatory demyelinating syndromes of the CNS. Talk with your doctor about the best course of treatment for your specific disorder. Physical therapy, occupational therapy and cognitive behavioral therapy can also help manage symptoms. ![]() Strategies to treat symptoms include medications to improve walking, spams, bladder dysfunction and others. The goal of treatment is to:Ī variety of drug therapies are recommended depending on your specific disorder. Early diagnosis and discussion of treatment options is important. The symptoms and progression of demyelinating diseases varies between patients. Disease-modifying therapies can be used together with symptomatic treatment. There is no cure for demyelinating diseases, but disease-modifying therapies can alter the disease progression in some patients. MS and other demyelinating diseases most commonly cause: Acute disseminated encephalomyelitis - inflammation of the brain and spinal cord.Transverse myelitis - inflammation of the spinal cord.Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) - inflammatory disorder of the central nervous system, predominantly of the optic nerve and spinal cord.Neuromyelitis optica spectrum disorder (NMOSD) - inflammation and demyelination of the central nervous system, especially of the optic nerve and spinal cord.Optic neuritis - inflammation of the optic nerve in one or both eyes.Other types of demyelinating disease and their causes include: The process can result in multiple areas of scarring (sclerosis). This attack causes inflammation and injury to the nerve sheath and ultimately to the nerve fibers that it surrounds. In this disorder, your immune system attacks the myelin sheath or the cells that produce and maintain it. Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system.
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